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Physiology

Vitamin d signaling, infectious diseases, and regulation of innate immunity. Infect Immun. 2008 Sep;76(9):3837–43.
20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation. J Invest Dermatol. 2008 Sep;128(9):2271–80.
The vitamin D receptor Fok1 polymorphism and bone mineral density in Chinese children. Clin Chim Acta. 2008 Sep;395(1–2):111–4.
Identification of the functional vitamin D response elements in the human MDR1 gene. Biochem Pharmacol. 2008 Aug 15;76(4):531–42.
Vitamin D analogs: Therapeutic applications and mechanisms for selectivity. Mol Aspects Med. 2008 May 1.
The controversial role of vitamin D in the skin: immunosuppression vs. photoprotection. Clin Exp Dermatol. 2008 Mar;33(2):167–70.
Characterizing Early Events Associated with the Activation of Target Genes by 1,25-Dihydroxyvitamin D3 in Mouse Kidney and Intestine in Vivo. J Biol Chem. Vol. 282, Issue 31, 22344–22352, August 3, 2007.
Modulatory effects of 1,25-dihydroxyvitamin d3 on human B cell differentiation. J Immunol. 2007 Aug 1;179(3):1634–47.
What is new in vitamin D: 2006–2007. Curr Opin Rheumatol. 2007 Jul;19(4):383–8.
Lithocholic acid can carry out in vivo functions of vitamin D. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10006–9.
Activation of the human immunodeficiency virus type I long terminal repeat by 1alpha,25-dihydroxyvitamin D3. J Mol Endocrinol. 2007 Jun;38(6):587–601.
A Prospective Study of Plasma Vitamin D Metabolites, Vitamin D Receptor Polymorphisms, and Prostate Cancer. PLoS Med. 2007 March 20;4(3): e103.
Upregulation of Vitamin D binding protein (Gc-globulin) binding sites during neutrophil activation from a latent reservoir in azurophil granules. Mol Immunol. 2007 Mar;44(9):2370–7.
Role of nuclear hormone receptors in butyrate-mediated up-regulation of the antimicrobial peptide cathelicidin in epithelial colorectal cells. Molecular Immunology Volume 44, Issue 8, March 2007, Pages 2107–2114.
In vivo relevance for photoprotection by the vitamin D rapid response pathway. J Steroid Biochem Mol Biol. J Steroid Biochem Mol Biol. 2007 Mar;103(3–5):451–6.
1,25-Dihydroxyvitamin D(3) regulates genes responsible for detoxification in intestine. Toxicol Appl Pharmacol. 2007 Jan 1;218(1):37–44.
Cross-sectional analysis of abnormalities of mineral homeostasis, vitamin D and parathyroid hormone in a cohort of pre-dialysis patients. The chronic renal impairment in Birmingham (CRIB) study. Nephron Clin Pract. 2007;107(3):c109–16.
Mutational Analysis of the Vitamin D Receptor Does Not Support Its Candidacy as a Tumor Suppressor Gene in Parathyroid Adenomas. Journal of Clinical Endocrinology & Metabolism Vol. 91, No. 12 5019–5021.
Vitamin d receptor: new assignments for an already busy receptor. Endocrinology. 2006 Dec;147(12):5542–8.
Effects of 25-Hydroxyvitamin D3 and 1,25-Dihydroxyvitamin D3 on Cytokine Production by Human Decidual Cells. Biol Reprod. 2006 Dec;75(6):816–22.
Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta. 2006 Oct;372(1–2):33–42.
Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids. 2006 Oct;71(10):849–56.
1,25-Dihydroxyvitamin D3 inhibits tumor necrosis factor-alpha-induced adhesion molecule expression in endothelial cells. Cell Biol Int. 2006 Apr;30(4):365–75.
Vitamin D physiology. Prog Biophys Mol Biol. 2006 Sep;92(1):4–8. Review.
1alpha,25(OH)(2)-Vitamin D(3) stimulates intestinal cell p38 MAPK activity and increases c-Fos expression. Int J Biochem Cell Biol. 2006 Jul;38(7):1181–90.
Cardiovascular disease in chronic kidney failure: the role of VDR activators. Curr Opin Investig Drugs. 2006 Mar;7(3):206–13. Review.
24,25-dihydroxyvitamin D(3) binds to catalase. J Cell Biochem. 2006 Mar 21;97(6):1259–1266
Programmed cell death of stressed keratinocytes and its inhibition by vitamin D: The role of death and survival signaling pathways. Apoptosis. 2006 Apr;11(4):519–34.
Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. J. Clin. Invest. 116:1703–1712 (2006) March.
Vitamin D signaling is modulated on multiple levels in health and disease. Mol Cell Endocrinol. 2006 Mar 27;248(1–2):149–59. Review.
New insights into mineral and skeletal regulation by active forms of vitamin D. Kidney Int. 2006 Jan;69(2):218–23. Review.
Genetic Ablation of Vitamin D Activation Pathway Reverses Biochemical and Skeletal Anomalies in Fgf-23-Null Animals. American Journal of Pathology. 2006;169:2161–2170.
Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse. Endocrinology. 2005 Feb;146(2):825–34.
Vitamin D: a hormone for all seasons—how much is enough? Clin Biochem Rev. 2005 Feb;26(1):21–32.
Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3 FASEB. 2005;19:1067–1077.
Vitamin D2 Is Much Less Effective than Vitamin D3 in Humans. Journal of Clinical Endocrinology & Metabolism 2004 Aug Vol. 89, No. 11 5387–5391.
Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients. Nutr J. 2004 Jul 19;3:8.
Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr. 2003 May;89(5):552–72. Review.
Vitamin D receptor as a drug discovery target. Mini Rev Med Chem. 2003 May;3(3):193–204. Review.
Vitamin D: A millenium perspective. J Cell Biochem. 2003 Feb 1;88(2):296–307. Review.
Evolution and function of vitamin D. Recent Results Cancer Res. 2003;164:3–28. Review.
Vitamin D insufficiency: no recommended dietary allowance exists for this nutrient. CMAJ. 2002 Jun 11;166(12):1541–2. Comment.
CD8(+) T cells are not necessary for 1 alpha,25-dihydroxyvitamin D(3) to suppress experimental autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5557–60.
Vitamin D and genomic stability. Mutat Res. 2001 Apr 18;475(1–2):69–87. Review.
Calcium and vitamin D. Diagnostics and therapeutics. Clin Lab Med. 2000 Sep;20(3):569–90. Review.
An evaluation of the biologic activity and vitamin D receptor binding affinity of the photoisomers of vitamin D3 and previtamin D3. J Nutr Biochem. 2000 May;11(5):267–72.
Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2. Am J Clin Nutr. 1998 Oct;68(4):854–8.
The photoprotective effect of 1,25-dihydroxyvitamin D3 on ultraviolet light B-induced damage in keratinocyte and its mechanism of action. J Dermatol Sci. 1998 Sep;18(1):11–8.
Mechanisms and functions of vitamin D. Nutr Rev. 1998 Feb;56(2 Pt 2):S4–10; discussion S 54–75. Review.
Calcium absorptive effects of vitamin D and its major metabolites. J Clin Endocrinol Metab. 1997 Dec;82(12):4111–6.
Vitamin D metabolism in human colon adenocarcinoma-derived Caco-2 cells: expression of 25-hydroxyvitamin D3-1alpha-hydroxylase activity and regulation of side-chain metabolism. J Steroid Biochem Mol Biol. 1997 May;62(1):21–8.
Bioavailability of vitamin D. Eur J Clin Nutr. 1997 Jan;51 Suppl 1:S76–9. Review.
The effect of season and latitude on in vitro vitamin D formation by sunlight in South Africa. S Afr Med J. 1996 Oct;86(10):1270–2.
Stable expression of the nuclear vitamin D receptor in the human prostatic carcinoma cell line JCA-1: evidence that the antiproliferative effects of 1 alpha, 25-dihydroxyvitamin D3 are mediated exclusively through the genomic signaling pathway. Endocrinology. 1996 May;137(5):1554–61.
Single-dose cholecalciferol suppresses the winter increase in parathyroid hormone concentrations in healthy older men and women: a randomized trial. Am J Clin Nutr. 1994 May;59(5):1040–4.
Effects of skin thickness, age, body fat, and sunlight on serum 25-hydroxyvitamin D. Am J Clin Nutr. 1993 Dec;58(6):882–5.
Selective biological response by target organs (intestine, kidney, and bone) to 1,25-dihydroxyvitamin D3 and two analogues. Cancer Res. 1993 Sep 1;53(17):3935–42.
Biological activity assessment of 1 alpha,25-dihydroxyvitamin D3-26,23-lactone and its intermediate metabolites in vivo and in vitro. Endocrinology. 1990 Aug;127(2):695–701.
The role of the vitamin D endocrine system in health and disease. N Engl J Med. 1989 Apr 13;320(15):980–91. Review.
Regulation of metallothionein gene expression by 1 alpha,25-dihydroxyvitamin D3 in cultured cells and in mice. Proc Natl Acad Sci U S A. 1987 Dec;84(24):8810–3.
Synthesis and biological activity of 1 alpha,23,25,26-tetrahydroxyvitamin D3. Arch Biochem Biophys. 1987 Apr;254(1):188–95.
Photosynthesis of vitamin D in the skin: effect of environmental and life-style variables. Fed Proc. 1987 Apr;46(5):1876–82.
Synthesis of vitamin D by the skin. Wiad Lek. 1987 Mar 15;40(6):413–9. In Polish.
The difference of biological activity among four diastereoisomers of 1 alpha,25-dihydroxycholecalciferol-26,23-lactone. J Steroid Biochem. 1986 Oct;25(4):505–10.
The metabolism and functions of vitamin D. Adv Exp Med Biol. 1986;196:361–75. Review.
Vitamin D absorption in healthy subjects and in patients with intestinal malabsorption syndromes. Am J Clin Nutr. 1985 Oct;42(4):644–9.
Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985 Oct;76(4):1536–8.
Synthesis of Vitamin D in the skin. Postepy Hig Med Dosw. 1985 Jan–Feb;39(1):85–104. Review in Polish.
Environmental light: effects on vitamin D synthesis and calcium metabolism in humans. Ann N Y Acad Sci. 1985;453:14–20.
Metabolism of 1,25-dihydroxyvitamin D3. Physiol Rev. 1984 Apr;64(2):478–504. Review.
Measurement of vitamin D metabolites in anephric subjects. Nephron. 1984;36(4):230–4.
Vitamin D: recent advances. Annu Rev Biochem. 1983;52:411–39. Review.
Vitamin D from skin: contribution to vitamin D status compared with oral vitamin D in normal and anticonvulsant-treated subjects. Clin Sci (Lond). 1982 Nov;63(5):461–72.
Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin. Science. 1982 May 28;216(4549):1001–3.
Vitamin-D synthesis and metabolism after ultraviolet irradiation of normal and vitamin-D-deficient subjects. N Engl J Med. 1982 Mar 25;306(12):722–5.
Vitamin D nutrition increases skin tyrosinase response to exposure to ultraviolet radiation. Mol Cell Endocrinol. 1982 Mar;25(3):295–302.
Absence of seasonal variation in serum concentrations of 1,25-dihydroxyvitamin D despite a rise in 25-hydroxyvitamin D in summer. J Clin Endocrinol Metab. 1981 Jul;53(1):139–42.
The cutaneous photosynthesis of previtamin D3: a unique photoendocrine system. J Invest Dermatol. 1981 Jul;77(1):51–8.
Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an essential regulator. Science. 1981 Feb 6;211(4482):590–3.
Photosynthesis of previtamin D3 in human skin and the physiologic consequences. Science. 1980 Oct 10;210(4466):203–5.
Vitamin D metabolism in kidney insufficiency: disorders of an endocrine regulatory zone. Klin Wochenschr. 1979 Oct 1;57(19):1053–9. Review in German.
Physiologic implications of the formation of previtamin D3 in skin. Trans Assoc Am Physicians. 1979;92:54–63.
Previtamin D3 from skin. Nutr Rev. 1979 Jun;37(6):203–5.
Interrelationships between the key elements of the vitamin D endocrine system: 25-OH-D3-1-hydroxylase, serum calcium and phosphorus levels, intestinal 1,25(OH)2D3, and intestinal calcium binding protein. Adv Exp Med Biol. 1977;81:211–31. Review.
Regulation of vitamin D metabolism in the kidney. Adv Exp Med Biol. 1977;81:195–209. Review.
The regulation of vitamin D metabolism. Adv Exp Med Biol. 1977;81:251–61.
Metabolism of vitamin D: current status. Am J Clin Nutr. 1976 Nov;29(11):1258–70.
Vitamin D: the discovery of its metabolites and their therapeutic applications. Pediatrics. 1976 May;57(5):729–41. Review.
Recent advances in our understanding of the vitamin D endocrine system. J Lab Clin Med. 1976 Jan;87(1):7–26. Review.
Factors in human vitamin D nutrition and in the production and cure of classical rickets. Proc Nutr Soc. 1975 Sep;34(2):119–30. Review.
The kidney as an endocrine organ involved in the function of vitamin D. Am J Med. 1975 Jan;58(1):39–47. Review.
Evidence for the biologically active form of cholecalciferol in the intestine. J Biol Chem. 1970 Mar 10;245(5):1190–6.
Chromosomal receptor for a vitamin D metabolite. Proc Natl Acad Sci U S A. 1969 Jan;62(1):155–62.
The association of a metabolite of vitamin D3 with intestinal mucosa chromatin in vivo. J Biol Chem. 1968 Aug 10;243(15):4055–64.

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Vitamin D On The Web

Physiology